From the publishers of JADPRO

Graft-vs.-Host Disease Resource Center

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Bone Marrow Transplantation

Post-transplant cyclophosphamide, calcineurin inhibitor, and mycophenolate mofetil compared to anti-thymocyte globulin, calcineurin inhibitor, and methotrexate combinations as graft-versus-host disease prophylaxis post allogeneic stem cell transplantation from sibling and unrelated donors in patients with acute myeloid leukemia: a study on behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

European Journal of Haematology

Post-transplant-cyclophosphamide and short-term Everolimus as graft-versus-host-prophylaxis in patients with relapsed/refractory lymphoma and myeloma—Final results of the phase II OCTET-EVER trial

JAMA Dermatology

Patient-reported outcomes and mortality in cutaneous chronic graft-vs-host disease

Blood

Younger unrelated donors may be preferable over HLA match in the PTCy era: A study from the ALWP of the EBMT

Bone Marrow Transplantation

Galectin-3 predicts acute GvHD and overall mortality post reduced intensity allo-HCT: a BMT-CTN biorepository study

Transplantation and Cellular Therapy

Easix score correlates with endothelial dysfunction biomarkers and predicts risk of acute graft-versus-host disease after allogeneic transplantation

Bone Marrow Transplantation

Graft-versus-host-disease prophylaxis with ATG or PTCY in patients with lymphoproliferative disorders undergoing reduced intensity conditioning regimen HCT from one antigen mismatched unrelated donor

Bone Marrow Transplantation

Graft-versus-host disease and impact on relapse in myelofibrosis undergoing hematopoietic stem cell transplantation

Transplantation Proceedings

Clinical and economic burden associated with acute graft-versus-host disease after allogeneic hematopoietic cell transplantation in Germany

Bone Marrow Transplantation

Fecal microbiota transplantation in capsules for the treatment of steroid refractory and steroid dependent acute graft vs. host disease: a pilot study

PLOS One

The effect of oral chronic graft-versus-host disease on bodyweight: A cohort study

Advances in Hematology

Novel pharmacological treatment options of steroid-refractory graft-versus-host disease

Clinical Cancer Research

Targeting hedgehog signaling with glasdegib in patients with refractory sclerotic chronic GVHD: A report of two phase I/II trials

2023 American Society of Hematology Annual Meeting Abstract

Safety and efficacy of axatilimab at 3 different doses in patients with chronic graft-versus-host disease (AGAVE-201)

Bone Marrow Transplantation

Post-transplantation cyclophosphamide is associated with increased bacterial infections

Frontiers in Pediatrics

Hospital survival following pediatric HSCT: changes in complications, ICU therapies and outcomes over 10 years

Transplantation and Cellular Therapy

Sirolimus is an acceptable alternative to tacrolimus for graft-versus-host disease prophylaxis after haploidentical peripheral blood stem cell transplantation with post-transplant

Regulatory Focus

FDA guidance explores trial design, supporting data for GVHD treatments

Bone Marrow Transplantation

Acute GVHD classification based on the dynamics of GVHD skin involvement from its appearance to the start of systemic treatment

Pediatric Blood & Cancer

Prophylactic donor lymphocyte infusion after haploidentical hematopoietic cell transplantation and post-transplant cyclophosphamide for treatment of high-risk myeloid neoplasms in children: A retrospective study

Blood

How I prevent GVHD in high-risk patients: posttransplant cyclophosphamide and beyond

Clinical Journal of Oncology Nursing

Treatment and nursing for steroid-refractory acute graft-versus-host disease

Annals of Hematology

Salvage hematopoietic stem cell transplantation for patients with higher leukemia burden in relapsed or refractory acute myeloid leukemia: A ten-year study

Bone Marrow Transplantation

Metabolic syndrome prevalence and impact on outcomes in patients with chronic graft-versus-host disease

OncLive

Axatilimab meets ORR end point in chronic GVHD after 2 or more prior lines of therapy

Annals of Hematology

Ruxolitinib versus basiliximab for steroid-refractory acute graft-versus-host disease: A retrospective study

Blood

Novel developments in the prophylaxis and treatment of acute GVHD

Bone Marrow Transplantation

Predictors and significance of kidney dysfunction in patients with chronic graft-versus-host disease

Blood Advances

Incidence, clinical presentation, risk factors, outcomes, and biomarkers in de novo late acute GVHD

Blood Cell Therapy

Novel insights into GVHD and immune reconstitution after allogeneic hematopoietic cell transplantation

Cancers

Graft-versus-host disease prophylaxis with antithymocyte globulin in patients receiving stem cell transplantation from unrelated donors: An observational retrospective single-center study

Blood Cell Therapy

Novel insights into GVHD and immune reconstitution after allogeneic hematopoietic cell transplantation

Blood Advances

Incidence, clinical presentation, risk factors, outcomes, and biomarkers in de novo late acute GVHD

The New England Journal of Medicine

Post-transplantation cyclophosphamide-based graft-versus-host disease prophylaxis

JAMA Open Network

Analysis of antibiotic exposure and development of acute graft-vs-host disease following allogeneic hematopoietic cell transplantation

Blood

Prognostic value of blood biomarkers in steroid-refractory or steroid-dependent acute graft-versus-host disease: a REACH2 analysis

Blood Cell Therapy

Utility of eGVHD App for bedside GVHD assessment in a high-volume BMT center

Annals of Hematology

Safety and efficacy of mesenchymal stromal cell therapy for multi-drug-resistant acute and late-acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation

Transplantation and Cellular Therapy

Impact of chronic graft-versus-host disease (GVHD) on patients’ employment, income, and informal caregiver burden: Findings from the Living with Chronic GVHD Patient Survey

Indian Journal of Ophthalmology

Dry eye disease and risk factors for corneal complications in chronic ocular graft-versus-host disease

Clinical Advances in Hematology & Oncology

Highlights in graft-versus-host disease from the 2023 Tandem Meetings | Transplantation & Cellular Therapy Meetings of ASTCT and CIBMTR

Critical Reviews in Oncology/Hematology

Recent advances and research progress in biomarkers for chronic graft versus host disease

Frontiers in Immunology

Exosomes, MDSCs and Tregs: A new frontier for GVHD prevention and treatment

Frontiers in Medicine

Post-transplantation cyclophosphamide combined with tacrolimus and low-dose post-engraftment anti-thymoglobulin as GVHD prophylaxis for patients undergoing peripheral blood stem cell transplantation from haploidentical family donor: A single center analysis

Blood

Phase II clinical trial evaluating abatacept in patients with steroid-refractory chronic graft versus host disease

JAMA Dermatology

Prognostic value of cutaneous disease severity estimates on survival outcomes in patients with chronic graft-vs-host disease

Transplantation and Cellular Therapy

Frailty in patients with chronic graft-versus-host disease

Nature

Pediatric chronic graft-versus-host disease-related dry eye disease and the diagnostic association of potential clinical findings

Transplantation and Cellular Therapy

Extracorporeal photopheresis as graft-versus-host disease prophylaxis: A randomized controlled trial

Blood

Effective treatment of low-risk acute GVHD with itacitinib monotherapy

Transplantation and Cellular Therapy

A Calcineurin Inhibitor Free Graft Versus Host Disease Prophylaxis for Patients Undergoing Matched Related and Matched Unrelated Donor Allogeneic Hematopoietic Cell Transplant

Journal of Clinical Oncology

Ibrutinib for First-Line Treatment of Chronic Graft-Versus-Host Disease: Results From the Randomized Phase III iNTEGRATE Study

Transplantation and Cellular Therapy

A Multiparameter Prognostic Risk Score of Chronic GVHD based on CXCL10 and Plasmacytoid DC (pDC) levels in the Peripheral Blood at 3 months after Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)

Blood

Prognostic Value of Blood Biomarkers in Steroid-Refractory/Dependent Acute Graft-vs-Host Disease: A REACH2 Analysis

Transplantation and Cellular Therapy

Chronic graft-versus-host-disease treatment in Brazil: analyses of failure-free survival

Bone Marrow Transplantation

Nilotinib efficacy and safety as salvage treatment following imatinib intolerance and/or inefficacy in steroid refractory chronic graft-versus-host-disease (SR-cGVHD)

Transplantation and Cellular Therapy

Pericardial effusion as a purported manifestation of graft versus host disease following allogeneic hematopoietic cell transplantation

Blood

How I prevent GVHD in high-risk patients: posttransplant cyclophosphamide and beyond

Hematologist: ASH News and Publications

For patients facing chronic GvHD, 2022 was a breakthrough year

2022 ASH Annual Meeting

A Real-World Evidence Comparison of 1-Year Overall Survival and Relapse-Free Survival between Patients Treated with Abatacept in Combination with a Calcineurin Inhibitor and Methotrexate Versus Antithymocyte Globulin or Post-Transplant Cyclophosphamide Following alloHCT

Journal of Clinical Oncology

Axatilimab for Chronic Graft-Versus-Host Disease After Failure of at Least Two Prior Systemic Therapies: Results of a Phase I/II Study

Translation and Cellular Therapy

Impact of conditioning regimen and graft-versus-host disease prophylaxis on the outcome of haploidentical peripheral blood stem cell transplantation for high-risk severe aplastic anaemia in children and young adults

Blood

Prevention of acute GVHD disease using an orthogonal IL-2/IL-2Rβ system to selectively expand regulatory T-cells in vivo

Translation and Cellular Therapy

A phase I trial of SYK inhibition with fostamatinib in the prevention and treatment of chronic graft-versus-host disease

Blood

Effective treatment of low risk acute GVHD with itacitinib monotherapy

Oncologist

Recent FDA Approvals in the Treatment of Graft-Versus-Host Disease

2022 ASH Annual Meeting

363 Phase I/II Clinical Trials of Donor-Derived Purified Regulatory T Cells for the Treatment of Steroid-Refractory Chronic Graft Versus Host Disease

2022 ASH Annual Meeting

574 Addition of Ruxolitinb to Corticosteroids As First-Line Therapy for High-Risk Acute Graft Versus Host Disease in Allogeneic Peripheral Blood Stem Cell Transplantation

2022 ASH Annual Meeting

265 Precision-Engineered Cell Therapy Orca-T Demonstrates High Relapse-Free Survival at 1 Year While Reducing Graft-Versus-Host Disease and Toxicity

2022 ASH Annual Meeting

LBA-4 Post-Transplant Cyclophosphamide, Tacrolimus, and Mycophenolate Mofetil As the New Standard for Graft-Versus-Host Disease (GVHD) Prophylaxis in Reduced Intensity Conditioning: Results from Phase III BMT CTN 1703

Transplantation and Cellular Therapy

Humoral and Cellular Immune Response to Covid-19 Vaccination in Patients with Chronic Graft-versus-Host Disease on Immunosuppression

Journal of Clinical Oncology

Burden of Long-Term Morbidity Borne by Survivors of Acute Myeloid Leukemia Treated With Blood or Marrow Transplantation: The Results of the BMT Survivor Study

Nature

Interstitial lung diseases after hematopoietic stem cell transplantation: New pattern of lung chronic graft-versus-host disease?

Transplantation and Cellular Therapy

Profiling the fungal microbiome after FMT for graft-versus-host disease: insights from a phase 1 interventional study

Blood

A diagnostic classifier for pediatric chronic graft-versus-host disease: results of the ABLE / PBMTC 1202 study

Transplantation and Cellular Therapy

Desiccating Stress Significantly Increases the Risk for Chronic Ocular Graft-versus-Host-Disease

Blood

Effective treatment of low risk acute GVHD with itacitinib monotherapy

Transplantation and Cellular Therapy

Late Effects of Severe Acute Graft-versus-Host Disease on Quality of Life, Medical Comorbidities, and Survival

Blood

MicroRNA serum profiles and chronic graft-versus-host disease

Nature

Safety and efficacy of fecal microbiota transplantation in the treatment of graft-versus-host disease

Nature

Disease progression, treatments, hospitalization, and clinical outcomes in acute GVHD: a multicenter chart review

Transplantation and Cellular Therapy

Post-transplantation cyclophosphamide vs tacrolimus and methotrexate graft-versus-host disease prophylaxis for HLA-matched donor transplantation

Blood Advances

Organ-specific response after low-dose interleukin-2 therapy for steroid-refractory chronic graft-versus-host disease

Transplantation and Cellular Therapy

Healthcare resource utilization and costs of steroid-associated complications in patients with graft-versus-host disease

Nature

Long-term clinical outcomes and predictive factors in patients with chronic ocular graft-versus-host disease

Blood Advances

Posttransplant cyclophosphamide for prevention of graft-versus-host disease: results of the prospective randomized HOVON-96 trial

Journal of Clinical Medicine

Impact of Cryopreservation of Peripheral Blood Stem Cells (PBSC) in Transplantation from Matched Unrelated Donor (MUD)

Clinical Cancer Research

FDA Approval Summary: Belumosudil for Adult and Pediatric Patients 12 Years and Older with Chronic GvHD after Two or More Prior Lines of Systemic Therapy

Clinical and Experimental Optometry

Keeping an 'eye' on ocular GVHD

Transplantation and Cellular Therapy

Neuropathy and Muscle Cramps in Autologous and Allogeneic Hematopoietic Cell Transplantation Survivors

Blood Advances

Prospective external validation of biomarkers to predict acute graft-versus host disease severity

Transplantation and Cellular Therapy

Low-intensity immunosuppressive therapy for chronic graft-versus-host disease

JCO Oncology Practice

Health literacy and clinical outcomes following hematopoietic stem-cell transplantation

Transplantation and Cellular Therapy

Correlation of patient-reported outcomes with clinical organ responses: data from the Belumosudil chronic graft-versus-host disease studies

Blood Advances

Assessment of systemic and gastrointestinal tissue damage biomarkers for GVHD risk stratification

Transplant and Cellular Therapy

Toward a Better Understanding of the Atypical Features of Chronic Graft-Versus-Host Disease: A Report from the 2020 National Institutes of Health Consensus Project Task Force

JAMA

Reducing graft-vs-host disease in blood stem cell transplants

Blood

Dual inhibition of the MEK/ERK and PI3K/AKT pathways prevents pulmonary GVHD suppressing perivenulitis and bronchiolitis

Blood Advances

Prediction of outcomes after second-line treatment for acute graft-versus-host disease

ASCO Annual Meeting

Ruxolitinib in chronic steroid-refractory graft-versus-host-disease

ASCO Annual Meeting

Incidence of chronic graft versus host disease using post-transplant cyclophosphamide in HLA-matched versus haploidentical donors

The ASCO Post

Abatacept for prophylaxis of acute graft-vs-host disease

Blood

A phase 1 study of donor regulatory T-cell infusion plus low-dose interleukin-2 for steroid-refractory chronic graft-vs-host disease

Journal of Clinical Oncology

Naive T-cell depletion to prevent chronic graft-versus-host disease

Transplantation and Cellular Therapy

Healthcare resource utilization and costs of steroid-associated complications in patients with graft-versus-host disease

Targeted Oncology

Acute GVHD responds quickly to itolizumab treatment in phase 1b trial

Elevated Bilirubin Following Engraftment: Differentiating SOS/VOD From GVHD

Management of Chronic Oral GVHD in Patient with High-Risk AML and Mixed Chimerism

Patient With History of Acute Steroid-Dependent Skin GVHD Develops Chronic GVHD: Part 2