CD70 CAR T cells secreting an anti-CD33/anti-CD3 dual-targeting antibody overcome antigen heterogeneity in AML

Last Updated: Friday, July 17, 2026

Researchers investigated the combined targeting of CD70 and CD33 to overcome acute myeloid leukemia antigen heterogeneity. They found that CD70-targeted CAR T cells secreting a CD33 T-cell–engaging antibody molecule showed feasibility in overcoming AML heterogeneity and leveraging patients’ bystander T cells.

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